Amy Nicholson

Host (Chapter 1: 'Wind') (voice)

Rodney Ascher

Host (Chapter 2: 'Membranes') (voice)

John Waters

Host (Chapter 3: 'Kindred') (voice)

Karyn Kusama

Host (Chapter 4: 'Multitudes') (voice)

Justin Benson

Host (Chapter 5: 'Judy') (voice)

Aaron Moorhead

Host (Chapter 5: 'Judy') (voice)

David Lowery

Host (Chapter 6: 'Dig') (voice)

David Lynch

self (archival footage)

Nicolas Cage

Sailor Ripley [archival]

Clint Eastwood

Self (archive footage)